Penicillin is a drug commonly used as an antibiotic agent. It is among the earliest discoveries made. It is a natural compound released to the environment by fungi (Penicillium notatum). Penicillin was discovered by Alexander Fleming in 1928 (Davies and Davies, 2010).

 Penicillin is found in various diverse forms and mostly obtained from Penicillium. The basic structures of penicillin and its derivatives are generally very similar and closely related. Penicillin and its derivatives generally have the similar basic ring β-lactam structure, which is formed by valine and cysteine amino acids through an intermediate tripeptide. The tripeptide third amino acid is substituted by an acyl group and this acyl group has specific functions and properties on penicillin and its derivatives

Penicillin G is one of the most used penicillin against microbes and it is not stable in gastric hydrochloric acid (Barker CI,2017). Oral intake of penicillin G is destroyed by stomach gastric acid before its absorbed in the blood and before it acts at the microbial infection site. Hence its route of administration is intra-muscular injection

penicillin is the most effective drug on Gram-positive bacteria. It is also known not to be effective on Gram-negative bacteria and fungi., penicillin act on the bacterial cell wall by breaking it down. Hence this leads to the death of the bacteria.Penicillin is a drug commonly used as an antibiotic agent. It is among the earliest discoveries made. It is a natural compound released to the environment by fungi (Penicillium notatum). Penicillin was discovered by Alexander Fleming in 1928 (Davies and Davies, 2010).

 Penicillin is found in various diverse forms and mostly obtained from Penicillium. The basic structures of penicillin and its derivatives are generally very similar and closely related. Penicillin and its derivatives generally have the similar basic ring β-lactam structure, which is formed by valine and cysteine amino acids through an intermediate tripeptide. The tripeptide third amino acid is substituted by an acyl group and this acyl group has specific functions and properties on penicillin and its derivatives

Penicillin G is one of the most used penicillin against microbes and it is not stable in gastric hydrochloric acid (Barker CI,2017). Oral intake of penicillin G is destroyed by stomach gastric acid before its absorbed in the blood and before it acts at the microbial infection site. Hence its route of administration is intra-muscular injection

penicillin is the most effective drug on Gram-positive bacteria. It is also known not to be effective on Gram-negative bacteria and fungi., penicillin act on the bacterial cell wall by breaking it down. Hence this leads to the death of the bacteria.