Abstract The aim of this study was to estimate the levels of TNF-α in serum and gingival crevicular fluid, in patients with chronic periodontitis (CP), before and after phase I therapy with subgingival delivery of Hyaluronic acid (Gengigel Gel). A total of thirty subjects were included in this study; 20 CP patients as a study group (group I) and 10 systemically healthy subjects with clinically healthy gingiva as a control group (group II). The nonsurgical periodontal therapy (SRP) + HA gel were done in group I. Periodontal parameters, including PI, GI, BOP, PD and the CAL, were recorded. GCF and serum were collected from all individuals included in the study; the first sample was collected from all groups (study and control) before treatment. The second sample was collected 4 weeks after subgingival delivery of Hyaluronic acid & phase I therapy from group I. Levels of TNF-α in GCF and serum were quantified using ELISA. The results showed a statistically significant reduction in total levels of TNF-α in serum and TNF-α in GCF in study group after application of Hyaluronic acid with phase I therapy. Results also showed all clinical parameters were significantly improved after application of Hyaluronic acid with phase I therapy in groups I (p<0.001). Scaling and root planing (SRP) is the mainstay of treatment of periodontal diseases, furthermore subgingival application of Hyaluronic acid gel with SRP were effective in improving clinical parameters in CP patients. TNF-α level in serum and GCF are reduced after phase I therapy with application of Hyaluronic acid.

Abstract

Purpose: The purpose of this study was to evaluate the fitness of mandibular Kennedy class I PEEK removable partial dentures fabricated with various techniques.

Materials and Methods: Six patients were selected for this study with maxillary completely edentulous arch against mandibular distal extension ridges posterior to canine teeth. each patient was randomly given the following frameworks in a crossover design; Group I: All patients were received PEEK frameworks fabricated by milling via CAD-CAM technique (PEEK disc were used). Group II: All patients were received PEEK frameworks fabricated by injection molding technique (Granular form of medical grade PEEK). For each framework (milled & injected), the fitness evaluation were done by measuring the gap between the framework and oral structures by evaluation the thickness of light body poly vinyl- siloxane impression material.

Results: The mean overall and site specific values of Gap distance beneath frameworks fabricated by CAD-CAM technique was significantly higher than the mean values of Gap distance in frameworks fabricated by injection technique.

Conclusion: Within the limitations of this short-term clinical study it was concluded that: 1) The fitness of both techniques of the RPD PEEK BioHPP frameworks manufacture were clinically accepted by the participants. 2) The RPD PEEK BioHPP frameworks manufactured by CAD / CAM was less fitness values than BioHPP frameworks constructed by Injection molding technique.